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Simulate Breathing Patterns for Inhaler Testing

The automated features of the BRS series calculate duration, frequency and I:E ratio and are an important component for IVIVC testing.

Breathing Simulators BRS

BRS Series

The Breathing Simulator (BRS) family of products was originally designed around the nebulizer requirement to test under tidal breathing. Today, BRS products are increasingly being used to replace constant flow rate (square wave) conditions to more closely represent conditions in vivo.

Unlike the traditional ventilator simulator systems, the BRS series was specifically designed to meet USP <1602> & <1602> specifications, automating the critical calculations of duration, frequency of breath, I:E ratio, etc.

Our suite of products is designed specifically for each individual application in OINDP testing. The upper end models have very flexible computer-controlled breath profiles, ultimately enabling the next wave of IVIVC testing.

Explore the possibilities for enhanced IVIVCs and precise testing across sensitive OINDP scenarios.


  • Dry Powder Inhalers (DPI)
  • Nebulizers
  • Aqueous Droplet Inhalers

Features and Benefits

  • Creates a range of breathing profiles and tidal patterns for USP 1601, 1602 breathing profiles
  • 2100/3100 inhale and exhale profiles with programmable profiles, which can be tailored to a specific patient population
  • 3100 – 5L volume, 2100 – 0.9L volume, 1100 – 0.8L volume
  • Required for nebulizer testing
  • Programmable I/E ratios
  • Set number of breaths or duration of tidal breathing
MSP/TSI Model # Product Copley Part # Request a Quote
0001-01-9231 BRS100i Breathing Simulator 9131 Request a quote
0001-01-9176 BRS200i Breathing Simulator 9116 Request a quote
0001-01-9186 BRS300i Breathing Simulator 9126 Request a quote
0001-01-9551 BRS Qual Kit 9105 Request a quote

The complete product family is also featured in the Copley Catalog.


Service & Calibration

Mensuration and calibration are imperative in pharmaceutical testing, and is recommended by the FDA (Food and Drug Administration), USP (United States Pharmacopeia), and GMP (Good Manufacturing Practices).

Request service today

Calibration Contracts & Extended Warranties

MSP provides calibration and mensuration services, as well as calibration contracts and extended warranties as part of our QualityGuard™ program.

Each instrument model is unique, please refer to the model-specific service documentation for details on what each package includes: QualityGuard Information Brochure

Contact and Order

Contact the MSP Sales Team (MSPSales@tsi.com) to learn more and order your calibration contract and/or extended warranty by filling out the form below. You can also refer to our QualityGuard ordering brochure for additional detail, including how to ship your equipment to MSP.