简易冲击测量 (AIM) 设备

The Abbreviated Impactor Measurement (AIM) Method implies using a shorter process to characterize aerodynamic size. It has been promoted as an alternative to the labor-intensive full resolution cascade impactor methodology for APSD (aerodynamic particle size distribution) testing.

Using an AIM methodology for early stage development has become increasingly popular as both OINDP device and drug companies look for ways to shorten drug development. This technology has traditionally been limited to early development signals indicating rough drug particle size, and this equipment is still intended to categorize the entire dosage for effective mass balance exercises.

More recently the AIM methodology has been expanded into full submissions to the FDA for approval and the resulting ongoing quality control testing. Drug manufacturers use abbreviated impactors such as the FSA (Anderson version), the FSI (fast screening impactor), and the rNGI (reduced NGI) as tools to significantly reduce the time and effort spent in test collection and analysis. By using the correlating device, the results can easily be extrapolated and transferred to the full device (i.e. FSA results are transferred to the Andersen Impactor).

MSP carries a variety of AIM Methodology equipment, including the FSA, FSI, and rNGI. These products are also featured in the Copley Catalog, and part numbers for the Copley Catalog are included in the chart below.

• Fast Screening Andersen (FSA): AIM-modified version of the standard Andersen Cascade Impactor (ACI). The FSA is used during quality control and product development.
   
• Fast Screening Impactor (FSI): The FSI is designed using NGI principles and is suited for MDIs, DPIs, and nasal sprays. The FSI separates the inhaler device dose into Coarse Particle Mass (CPM), Fine Particle Mass (FPM) and a standard or custom cut point.
   
• Reduced NGI (rNGI): The rNGI can be used in quality control and/or AIM-HRT applications. Utilizing an existing NGI body, the rNGI provides a way to reduce the number of collection stages (and thusly chemical analysis) and is directly translatable back to an NGI. There are additional options available to further optimize and simplify the rNGI concept such as deep cups, bypass cups, etc.
   

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