In Vitro – In Vivo Correlation IVIVC Equipment

Alberta Idealized Throat (AIT)

Model Number: 0001-01-8511

The Alberta Idealized Throat (AIT) is a highly realistic throat model designed to improve in vivo testing for inhalation products.

Product Details

By mimicking the anatomy of the human throat, the AIT enhances the accuracy of aerodynamic particle size distribution (APSD) testing, making the data more representative of what actually enters the lungs. Available in both Child (6-14 years) and Adult models, the AIT is crafted to replicate key regions of the throat, including the oral cavity, pharynx, epiglottis, and larynx, ensuring realistic and reliable testing for inhaler devices.

The AIT is specifically designed to optimize the Impactor Sized Mass (ISM) data, providing results that better correlate with actual in vivo deposition in the lungs. It simplifies and enhances the drug recovery process by ensuring particles follow realistic paths through the throat before entering the impactor. The aluminum construction ensures durability and reproducibility, making it a long-lasting and reliable tool in APSD testing for inhaler products.

Applications

The AIT is ideal for improving the accuracy of APSD testing in the following devices, ensuring better representation of patient drug delivery.

  • Metered Dose Inhalers (MDI)
  • Dry Powder Inhalers (DPI)

Features and Benefits

  • USP 1602 Recommendation: Listed as an option to improve data collection accuracy in APSD testing.
  • Optimized for Patient Profiles: Available in Child and Adult models, designed to reflect diverse patient anatomies, validated through extensive research.
  • Chemical Compatibility: Works with a wide range of drug recovery solvents, simplifying the testing process.
  • Durable Construction: Manufactured from high-quality aluminum, ensuring longevity and consistent performance in all testing scenarios.

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