NGI and NGI Plus

NGI and NGI Plus systems are foundational tools for measuring aerodynamic particle size distribution in inhalation products. Their precisely engineered stages, paired with standardized throats and accessories, support high-quality data generation under pharmacopeial methods.

Performance and Usability

• Accurate stage cut-offs: Designed to deliver consistent size fractionation across a wide range of flow rates.
• NGI Plus enhancements: Streamlined handling and cleaning features help reduce turnaround time and support routine QC.
• Accessory ecosystem: Throats, pre-separators, induction ports, and sealing options support device-specific methods.
• Broad applicability: Suitable for pMDIs, DPIs, and SMIs across development and commercial testing.

Workflow Integration

• Actuation control: Pair with automated systems to standardize dose firing and shake profiles.
• Flow management: Use compatible controllers to achieve target flow rates and pressure drops for DPIs and critical flow for pMDIs.
• Sample preparation: Integrate with extraction units and mixers to help drive consistent recovery and mass balance.
• Data analysis software: Calculate MMAD, GSD, FPF, and more with templates that support method consistency.

Compliance Awareness

NGI-based testing aligns with guidance such as USP <601> and Ph. Eur. 2.9.18 for APSD. With appropriate method validation, documentation, and instrument maintenance, laboratories can produce robust, defensible data sets suitable for submissions and audits.

Use Cases

• Early formulation screening
• Device optimization and comparative studies
• Stability and robustness evaluations
• Routine QC and batch release testing

By combining NGI or NGI Plus with automation, environmental control, and structured data analysis, laboratories can achieve high productivity while maintaining strong data quality across the product lifecycle.