NGI Cup Coater

Particle bounce and re-entrainment can compromise the accuracy of Aerodynamic Particle Size Distribution (APSD) measurements in cascade impactors like the NGI or ACI for Orally Inhaled and Nasal Drug Products (OINDPs). This occurs when particles bounce back into the airflow, leading to an overestimation of the Fine Particle Dose (FPD).
 

The NGI Cup Coater mitigates this issue by applying a tacky coating (e.g., glycerol or silicone oil) to collection surfaces, ensuring better particle adhesion. This reduces bounce and enhances data accuracy, particularly for dry powder inhalers (DPIs) and metered-dose inhalers (MDIs). By standardizing the coating process, the NGI Cup Coater improves reproducibility, making it essential for precise inhaler testing.

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NGI Cup Coater 0001-01-5920

The NGI Cup Coater consistently coats the NGI cups to reduce particle bounce inherent in DPI...

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Consistent cup coating is a small step with a large impact on NGI results. The NGI Cup Coater brings control and repeatability to this preparation task, helping laboratories reduce variability tied to deposition and re-entrainment.

Why Coating Consistency Matters

  • Particle bounce reduction: Uniform coatings promote particle adhesion and stabilize stage-by-stage deposition.
  • Improved repeatability: Reduce run-to-run drift caused by inconsistent manual coating.
  • Faster prep: Streamline setup and keep NGI testing on schedule.

Key Features

  • Controlled application: Apply coatings to target thicknesses and coverage.
  • Repeatable methods: Save and reuse parameters for different formulations or studies.
  • Easy operation: Simple controls and quick cycles reduce training time.
  • Clean workflows: Minimize spills and variability with controlled processes.

Integration With NGI Workflows

  • Pair with NGI and NGI Plus: Enhance APSD reproducibility by standardizing pre-test preparation.
  • Combine with actuation and flow control: Build a comprehensive, controlled workflow from device firing to sample extraction.
  • Support data integrity: Link coating parameters with test records to provide context during review.

Use Cases

  • Development: Stabilize early experiments to focus on formulation and device variables.
  • QC: Maintain consistent preparation across operators and shifts.
  • Method transfer: Share coating parameters between sites to support comparable results.

By standardizing coating application, the NGI Cup Coater helps teams strengthen the reliability of APSD data and reduce preparation bottlenecks in busy laboratories.


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