Actuation variability is a common source of noise in inhalation studies. Automated inhaler and spray control systems address this challenge by applying programmable, repeatable motion profiles tailored to each device type. Whether you are executing APSD with NGI, conducting delivered dose uniformity tests, or performing priming and stability studies, controlled actuation helps drive consistent results.
Programmable Control
- Stroke length and actuation force: Adjust to device specifications and study needs.
- Shake and dwell: Apply pre-actuation shake profiles and hold times for pMDIs to support consistent aerosolization.
- Timing and cadence: Set delays, sequences, and repeat intervals to standardize workflows.
- Device fixtures: Use dedicated mounts and adapters for pMDIs, DPIs, SMIs, and nasal sprays.
Workflow Integration
- NGI and DDU: Combine actuation control with impactors and dose collection apparatus for turnkey test setups.
- Environmental conditioning: Perform actuation within or adjacent to controlled chambers for consistent preconditioning.
- Data linkages: Send actuation logs to analysis software to support data review and traceability.
Benefits Across the Product Lifecycle
- Development: Screen and compare devices and formulations with lower operator-to-operator variability.
- Method transfer: Replicate programmed profiles across sites to support smoother transfers.
- QC and stability: Execute routine runs quickly with less manual handling, supporting consistent batch-to-batch trending.
Standards Context
Automated actuation supports compendial test methods (for example, USP <601>, Ph. Eur. 2.9.18) by improving control over critical steps. When combined with validated software and structured documentation, laboratories can strengthen data integrity practices and create clear, auditable records.
By bringing precision, repeatability, and speed to actuation, these systems help teams focus on analytics and decision-making — where it matters most.
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